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Endocrine Abstracts

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ea0011p832 | Thyroid | ECE2006

Insulin-like growth factor-1 counteracts 131I-induced thyroid stunning by stimulating the transcription of the sodium/iodide symporter (NIS)

Nordén M , Johanson C , Tedelind S , Larsson F , Carlsson T , Nilsson M

Thyroid stunning means reduced radioiodine uptake in thyroid tissue or tumour following a diagnostic 131I test dose. This may compromise subsequent 131I radiotherapy. Recently, we found that 131I inhibits iodide uptake in cultured thyroid cells at non-lethal absorbed doses. Here, we have investigated whether 131I irradiation affects the TSH-stimulated transcription of the sodium/iodide symporter (NIS) gene, and whether insulin-like g...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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